Search on: 2 ISOPROPYLMALATE SYNTHASE 
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Descriptor English:   2-Isopropylmalate Synthase 
Descriptor Spanish:   2-Isopropilmalato Sintasa 
Descriptor Portuguese:   2-Isopropilmalato Sintase 
Synonyms English:   alpha-Isopropylmalate Synthase
2 Isopropylmalate Synthase
Synthase, 2-Isopropylmalate
Synthase, alpha-Isopropylmalate
alpha Isopropylmalate Synthase  
Tree Number:   D08.811.913.050.614
Definition English:   An enzyme that catalyzes the first step in the biosynthetic pathway to LEUCINE, forming isopropyl malate from acetyl-CoA and alpha-ketoisovaleric acid. This enzyme was formerly listed as EC 4.1.3.12. 
History Note English:   91(75); was see under KETOACID-LYASES 1975-90 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   7712 
Unique Identifier:   D015079 

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